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Melatonin-pretreated human umbilical cord mesenchymal stem cells improved endometrium regeneration and fertility recovery through macrophage Immunomodulation in rats with intrauterine adhesions [J]

This helped to show that NNMT is a key target in metabolic research. Neelakantan and colleagues then expanded research involving small-molecule NNMT inhibitors

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A recent study demonstrated that TSA protects myocardial ECs by stabilizing mitochondrial membrane potential, regulating calcium homeostasis and inhibiting endoplasmic reticulum stress markers (CHOP, PERK and ATF5) through enhancing the interaction between SIRT5 and methyl transferase-like 3 (100)

Hamza, T., Barnett, J