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Some of the biomarkers associated with aging include increased SA--Gal activity, elevated levels of p16INK4a and p21CIP1 (cell-cycle inhibitors), and SASP, a phenotype composed of cytokines, chemokines, metalloproteinases, growth factors, reactive metabolites, and extracellular vesicles

Hue, L., Bontemps, F

10.1016/S0891-5849(01)00480-4 Free Radic Biol Med

Here, we summarize the up-to-date evidence of pathophysiologic mechanisms and diagnosis/management approaches to the patients with NERD with its phenotypic classification

Furthermore, diverse adhesive domains/motifs, such as oligomerization domains, coiled coils, and -zippers, provide multiple intramolecular and intermolecular interactions (Fig