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2.2 Experimental design The Design Expert software (version 13, Stat-Ease Inc., Minneapolis, MN, United States) was employed to create a three-factor, three-level (3) Box-Behnken Design (BBD) with five center points, resulting in 17 experimental runs as depicted in Table 1

Yaodong Wang, [email protected] These authors have contributed equally to this work Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

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