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Bioelectrochemistry (2005) 65(2):15762

Langlais, D., Barreiro, L

Semin Radiat Oncol 13:176181

The consequences of these modifications are that IGF-1 LR3 retains the pharmacological activity of IGF-1 as an agonist of the IGF-1 receptor, has very low affinity for the insulin-like growth factor-binding proteins (IGFBPs), and has improved metabolic stability resulting in approximately three times greater potency than IGF-1, with a significantly longer half-life of about 2030 hours relative to IGF-1s half-life of about 1215 hours

Available from: Simes RR, Kraus SI, Coelho IS, Dal-Secco D, Siebert DA, Micke GA, et al