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Studies have reported that more than half of patients with ME/CFS reported at least one experience of early childhood trauma ( FIGURE 2 Mechanistically, early adversity and chronic stress may induce persistent biological changes through long-term stress programming and the HPA axis (Schr et al., 2022)

Gerontology 66 , 266274 (2020)

At Cymbiotika, we believe that understanding these reactions requires looking closely at how supplements are formulated and how the body absorbs them

DMF was also shown to diminish the metabolic flux of glutamine to the tricarboxylic acid (TCA) cycle and divert it towards GSH biosynthesis 26

NAC has been shown to increase production of glutathione, an important antioxidant in the body