napqi glutathione mechanism File:Acetaminophen metabolism.jpg Pharmacokinetic profile of metabolites by

Pharmacokinetic profile of metabolites by heart cutting two dimensional liquid chromatography: A focus on paracetamol analysis ScienceDirect Fasting depletes Glutathione, turning "safe" Paracetamol doses into a liver toxic emergency. Don't let a therapeutic dose become a lethal one. See the safety protocols on BMJ Best Practice via bio. #MedEd # Solved The following figure shows the metabolism of the 3 Glutathione Rescue Normally, glutathione binds NAPQI and converts it into non toxic byproducts (cysteine + mercapturic acid) that are excreted. Example: Glutathione is your liver's safety net against toxins. Paracetamol metabolism, hepatotoxicity, biomarkers and therapeutic interventions: a perspective PMC

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