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IGF-1 over-expressing mice showed hypermyelinated axons (Ye et al., 1995), whereas IGF-1 knockout mice exhibited a decreased number of oligodendrocytes and hypomyelination (Beck et al., 2002)

Summerskill, W

The PCR products were purified, digested with XhoI and BamHI, and cloned into pLG669z (Guarente and Ptashne, 1981)

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