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The present findings align with those of Bauer and colleagues, who histologically identified a subpopulation characterized by -SMA + FAP + FLS within the lining layer and -SMA + FLS surrounding blood vessels in the sublining layer of both OA and RA synovial tissues (76)

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Six studies used injections of specific receptor agonists or antagonists or other compounds applied to a localized brain region, nine used intracerebroventricular (ICV) injections, and one used ex-vivo slices from a specific brain region