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NFAT, another critical regulator of IL-2 expression 37 , was also increased in arrested cells compared to unstimulated cells, but its expression was comparable to non-arrested cells and lower than in released cells (Extended Data Fig

[DOI] [PMC free article] [PubMed] [Google Scholar] 175.Cavalieri E.L., Rogan E.G

Excessive or poorly targeted antioxidant intervention could theoretically alter normal signalling as well as damaging oxidation

Hence, pathways and mechanisms need to be investigated for possible pharmacological intervention

COVID-19 is considered a systemic disease, as it affects organs in the entire body (Guan et al