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Limitations : Invasive with risks (e.g., hypoparathyroidism, recurrent laryngeal nerve damage), necessitates lifelong thyroid hormone replacement therapy

Regions of deficient, more-than-adequate or high iodine intake may have more need for selenium owing to the capacity of selenoproteins to protect the thyroid from excessive hydrogen peroxide ( Reference Schomburg and Kohrle 71 ) and from inflammation ( Reference Schomburg and Kohrle 71 ) (see earlier)

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Transcriptional responses consistent with perturbation in dermo-epidermal homeostasis in septic sole ulceration