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The review focuses on summarizing and evaluating tissue engineering research, particularly the preclinical and clinical findings on the effects of various seed cells, bio-scaffolds, and bioactive factors on IVD, to explore a more comprehensive therapeutic approach

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In mice studies, giving T-1 has been shown to increase natural killer (NK) cell activity in mice with cancer, but not healthy mice, proving the selective action on those who may benefit from T-1 Peptide therapy

In germ-free mice, the absence of microbial signals results in reduced 5-HTR density and impaired serotonin signaling, effects that can be restored through probiotic supplementation (Pan et al., 2025)