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NAC may effectively reduce cardiac iron level, exert antioxidant and anti-inflammatory effects, improving cardiac and cognitive functions (Sumneang et al., 2019)

doi: 10.1038/s41467-021-23111-1 113 GuerreiroR.WojtasA.BrasJ.CarrasquilloM.RogaevaE.MajounieE.et al

BME, WM, MSM, PC, BO, RL and CG: Participated in the recovery of blood samples and carried out the biochemistry determinations

During oxidative stress, NRF2 monitors the cellular response to oxidative stress by mediating detoxification through dissociation from the cytoplasmic inhibitor Keap1, which then translocates to the nucleus and activates the NRF2 transcriptional gene to provide cellular protection against oxidative stress (Hayes and McMahon, 2009)

These can include Cushings syndrome, adrenal fatigue, high blood sugar, hypertension, and growth retardation in children