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20 NRF2 was first identified in 1994, 21 and by 1996, 22 it had been discovered that under oxidative stress conditions, it could activate the expression of antioxidative enzyme genes, including NQO1, GPX4, TXN, and PRDX1

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This commenter recommended that prior to adopting the Information Transfer PRO-PM, CMS provide guidance on how to allow patients to opt-out of the survey without opting out of important patient communications, such as appointment reminders

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