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Neonatal foals have a higher percentage of body water than adult horses (80% versus 60% total body water), and the extra 20% is primarily confined to the extracellular fluid, so the Vd of drugs such as gentamicin are higher in neonatal foals than older foals or adult horses

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- Conditions related to weakened immunity or inflammation

Since the cytoplasmic vacuolation may mimic microvesicular fatty change, a descriptive diagnosis of cytoplasmic vacuolation is recommended in the absence of electron microscopy or special immunostaining

However, its specificity for the fibrotic pathology of frozen shoulder makes it an important peptide to watch in this space