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(2020) Local administration of methylcobalamin for subacute ophthalmic herpetic neuralgia: a randomized, phase III clinical trial

| Target Concentration | BAC Water to Add | Dose per 10 units on syringe | |---------------------|-----------------|------------------------------| | 5mg/ml | 2.0ml | 0.5mg | | 10mg/ml | 1.0ml | 1.0mg | **Best for:** Patients on 1-2mg weekly doses during titration weeks 1-8

Understanding the intracellular action mechanisms of B vitamins in nociceptive pathways sheds light on their potential to lower excitability, reduce sensitization, modulate neuroinflammation, and impact neurotransmitter systems involved in pain modulation [54]