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doi: 10.5812/jjm.14814 317 ShuCGeLLiZChenBLiaoSLuLet al

DCA inhibits mitochondrial pyruvate dehydrogenase kinase that inactives the pyruvate dehydrogenase complex

Cross-sectional and longitudinal measures of chitinase proteins in amyotrophic lateral sclerosis and expression of CHI3L1 in activated astrocytes

If not treated, they can cause lasting damage

The current first-line treatment options are chelators (substances that bind copper, and allow it to be excreted from the body), are D-penicillamine and trientine salts