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Currently, Phase II clinical studies of UCB0599 are underway

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We found that, mechanistically, DON exposure blocks glycolysis and lactate production in porcine granulosa cells, reduces the level of H3K18la, inhibits the expression of STEAP3, leading to an increase in intracellular ferrous ions, thus inducing ferroptosis

[DOI] [PubMed] [Google Scholar] Demain A., Vaishnav P