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In this study, researchers used an animal model of cancer to establish the potential role of the ecosystem of the digestive tract, called the gut microbiome, in determining whether chemotherapy will be effective

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Recent drug discovery strategies are based on two criteria: first, compound structures that are distinct from bicalutamide and enzalutamide to avoid cross-resistance and, second, compounds that retain antagonist properties even for known AR mutant proteins that adopt agonist conformations when bound to current AR antagonists (also known as pan-antagonists)