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If you disbelieve the studies (which the failed replications support), then the dose question is moot

Chronically high urine vitamin C levels, due to megadosing with vitamin C supplements, can increase the risk of oxalate kidney stones [43, 44]

Hayford FEA, Ozturk M, Dolman RC, Blaauw R, Nienaber A, Loots DT, Brombacher F, Smuts CM, Parihar SP, Malan L

Some years ago researchers showed that biofilms might also be helping the Lyme-causing bacteria evade treatment.(1) These findings have excited Lyme researchers who have since been exploring various treatment strategies designed to target the entire bacterial colony