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Most common side effects of GHSs The potential side effects of GH secretagogues depend on the specific compound and may include: local reactions at the injection site fractal flushing nausea and digestive issues increased appetite and weight gain elevated prolactin levels elevated cortisol levels insulin resistance water retention All GHSs except Ibutamoren are applied via injections, which can lead to local adverse reactions such as pain, swelling, and redness at the injection site

Glutamate concentrations in neurons are highest at axon terminals, which means that axon terminals somehow restrict glutamate movement or local synthesis and utilization of glutamate, and glutaminase is responsible for glutamate synthesis in most neurons (Mrquez et al., 2009

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Interactions between natural products and cancer treatments: underlying mechanisms and clinical importance