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EGCG downregulates M1 markers (IL-6, TNF-, and IL-1) and upregulates M2 markers (IL-10 and NQO1) in microglia, thereby modulating the M1/M2 ratio and mitigating neurotoxicity and neuronal damage arising from microglial hyperactivity (13)

However, they can also cause gastrointestinal side effects such as nausea, bloating, and stomach sensitivity, especially in the early stages of treatment and dosage changes

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Targeting Co-Regulatory Feedback Loop of MYC and GSPT1 By MYC/GSPT1 Dual Degradation Is Synthetic Lethal in Combination with Ven/Aza in TP53 Mutant Acute Myeloid Leukemia Stem and Progenitor Cells

Of particular importance are the colonic microbial metaboliteslow-molecular-weight phenolic derivatives generated via gut microbiotawhich have recently attracted attention for their potential role in modulating inflammation ( Moreover, considerable interindividual variability in EC metabolism exists, predominantly driven by differences in gut microbiota composition and host enzymatic profiles ( To bridge these critical knowledge gaps, this review systematically explores the anti-inflammatory mechanisms of EC, emphasizing the interplay between its structural properties, metabolic fate, and the bioactivities of its microbial metabolites