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It has been found that the enzyme pyruvate carboxylase is required for glutathione synthesis in these islet cells, promoting their antioxidant capacity to counter the stress associated with high blood glucose levels

[DOI] [PubMed] [Google Scholar] 234.Angelova PR

However, apoptosis, necroptosis, ferroptosis, pyroptosis, cuproptosis, PANoptosis, NETosis, autophagy-dependent cell death, mitotic death, mithuosis, alkaliptosis, anoikis, autosis, disulfidptosis, entosis, oxeiptosis, and parthanatos are reported as distinct RCD modes with unique signal transduction pathways (Fig

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