chac1 glutathione CHAC1: a master regulator of oxidative stress and ferroptosis in human diseases and cancers BACH1–CHAC1–Glutathione Axis Aggravates Myocardial Ischemia–Reperfusion

BACH1CHAC1Glutathione Axis Aggravates Myocardial IschemiaReperfusion Injury by Enhancing Ferroptosis and Oxidative Stress CHAC1 degradation of glutathione enhances cystine starvation induced necroptosis and ferroptosis in human triple negative breast cancer cells via the GCN2 eIF2 ATF4 pathway Oncotarget TRIB3 increases cell resistance to arsenite toxicity by limiting the expression of the glutathione degrading enzyme CHAC1 ScienceDirect Dysregulated lipids homeostasis disrupts CHAC1 mediated ferroptosis driving fibroblast growth factor receptor tyrosine kinase inhibitor AZD4547 resistance in gastric cancer ScienceDirect Human CHAC1 Protein Degrades Glutathione, and mRNA Induction Is Regulated by the Transcription Factors ATF4 and ATF3 and a Bipartite ATF CRE Regulatory Element ScienceDirect

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