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Manczak M, Calkins MJ, Reddy PH

10.1073/pnas.90.17.7915 29

There are two primary approaches to drug discovery: phenotypic drug discovery 10,11 and target-based drug discovery (TBDD) 12,13,14

Tissue and Cell Type Considerations Research across different tissue models has revealed some cell-type-specific differences in how IGF-1 DES and IGF-1 LR3 behave: Smooth muscle cells: IGF-1 DES has been studied in smooth muscle cell migration and proliferation models

This mechanism allows individuals to experience fat reduction without the muscle growth or insulin resistance risks often associated with full-spectrum growth hormone therapies