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Although most proteins that differed in expression between APOE genotypes were sex dependent, GPT2, SUOX, and SSBP1 were affected in both sexes

Animal Model:Female rats of the Blue Spruce Farms (Sprague-Dawley) (280-330 g) [4] Dosage:2 mg/kg, 4 mg/kg, 8 mg/kg, 12 mg/kg Administration:Intraperitoneal injection Result:Increased water intake during the first hr in a dose-dependent fashion up to the highest dose administered (12 mg/kg)

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Thioredoxin has been shown to be a source of electrons for reduction and isomerization of disulfide bonds of ER client proteins (Poet et al., 2017)