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It might feel good initially, but it can also intensify any existing discomfort

ARTN 637743

The trial targets adults with a body mass index (BMI) of 30 or higher, or a BMI of 27 or higher if they have health issues related to being overweight, such as high blood pressure or sleep apnea

Calzada Ltd was aggressively pursuing this treatment route in the early 2010s, reporting in 2012 that AOD-9604 might promote cartilage creation and repair [in vitro] (Source)