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Furthermore, although iron promotes cell division and growth, it can also lead to cell damage, as excessive iron accumulation can be toxic, activating cell death signaling pathways through oxidative stress (20)

doi: 10.3389/fmicb.2016.00257 Received 22 December 2015 Accepted 16 February 2016 Published 03 March 2016 Volume 7 - 2016 Edited by Bryan Troxell, North Carolina State University, USA Reviewed by Timothy James Donohue, University of Wisconsin-Madison, USA

10.2174/2210315510999201210143035 288 TsaiL.-C.LinY.-W.HsiehC.-L

The Vineland Adaptive Behavior Scale (VABS) and glutathione redox metabolites were measured at baseline and at the end of the treatment period

Although such peptides are unable to pass through the BBB, it is a prevailing notion that some use receptor-mediated transcytosis [99]