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Also known as cobalamin, is a water-soluble vitamin that has many important functions throughout the body, including keeping nerves healthy, supporting the production of DNA and red blood cells, and maintaining normal brain function

2.9 Seahorse XF Mito Stress Test assay MEC-1 and HG-3 cells were seeded at a density of 1 10 6 cells/mL and incubated for 24 hours with DMSO and CB-839 at equitoxic concentrations based on the IC 50 values established during the MTS assay

The conjugations catalyzed by the GSTs occur between the nucleophilic GSH and the compounds possessing a sufficiently electrophilic center [25]

Note that icterus and cholestasis are not synonymous

To further assess target engagement in vitro, we used a competitive fluorescence polarization (FP) assay that reports on the displacement of pomalidomideBODIPY from purified preparations of recombinant CRBNDDB1 (ref