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To clarify whether increased Ssu72 activity can induce opposing metabolic phenotypes, further validation using complementary gain-of-function models, such as adipocyte-specific Ssu72 overexpression, is necessary

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The initial study showed that DS-8273a might be used to eliminate myeloid-derived suppressor cells in advanced cancer patients, but no objective response was seen (Dominguez et al., 2017)