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However, in the pivotal Phase IIb trial, it failed to demonstrate statistically significant weight loss compared to placebo at the primary endpoint, leading the developer (Metabolic Pharmaceuticals Ltd.) to terminate the commercial program

Very high values IGF-1 were associated with a better prognosis of ALS suggesting that functions related to IGF-1 could be involved in survival

It contributes to the metabolism of carbohydrates and fats, playing a role in energy production

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Possible side effects include: Mild soreness at the injection site Temporary redness or swelling Rarely, mild dizziness or headache In most cases, these effects are minor and resolve quickly