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Superoxide as a messenger of endothelial function

Pharmacology [edit] Pharmacodynamics [edit] Although the mechanism of action of valproate is not fully understood, [38] traditionally, its anticonvulsant effect has been attributed to the blockade of voltage-gated sodium channels and increased brain levels of the inhibitory synaptic neurotransmitter gamma-aminobutyric acid (GABA)

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Via a short hinge region, the DBD is connected to the Ligand-Binding Domain (LBD) to which androgenic ligands and AR antagonists bind and that contains a ligand-dependent transactivation domain [46, 47]