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Metformin is a first-line medication for type 2 diabetes and a central candidate in drug repurposing strategies for both antiaging and anticancer research

The sarcoplasmic reticulum (SR) plays a crucial role in storing and releasing calcium ions during muscle contraction

In addition, emerging evidence indicates that baicalein and baicalin modulate purinergic signalingdriven inflammatory amplification, particularly by inhibiting the Panx1/P2X7 receptor axis, thereby suppressing inflammasome activation and pyroptotic cell death in renal tubular epithelial cells (Fu et al