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Interestingly, epithelial cells originating from different regions of a nephron appeared to display diversified sensitivity to cisplatin

Particularly, absence seizure is common in children where metformin is rarely used

Moreover, platelet-derived growth factor receptor alpha (PDGFR + ) fibroblasts in lungs were shown to express IL-33 and thymic stromal lymphopoietin (TSLP), supporting ILC2 accumulation and activation in microenvironment niches 45

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They thus interfere with insulin action, determining a transient phase of hyperglycaemia and a prolonged pancreatic secretion of insulin and C-peptide