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In the chronic pain patient, the presence of a major depression is associated with reduced function, poorer outcome, and expanded health-care costs

C) is a Naturopathic Endocrinologist and the author of The NY Times bestselling Hormone Healing Cookbook, The Metabolism Reset Diet, and The Thyroid Reset Diet

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For quality control, we excluded participants who (1) have excess relatedness (more than 10 putative third-degree relatives), (2) have inconsistent information about sex based on genotyping and self-report, (3) have sex-chromosomes not XX or XY, (4) have poor-quality genotyping based on heterozygosity and missing rates, or (5) have withdrawn from UK Biobank

2011 Feb;14(1):4-10