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In vivo subcutaneous xenograft and orthotopic xenograft models All animal experiments were conducted in accordance with the Guide for the Care and Use of Laboratory Animals published by the Korea National Institute of Health (BEC-CAN-2016-001 and 002), and all studies were approved by the Institutional Animal Care and Use Committee of Yonsei University (IACUC-A-202204-1455-02, IACUC-A-202405-1856-01)

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This observation is also consistent with the weaker ATPase stimulation by hemin compared with CoPP, as the greater structural flexibility associated with hemin may lead to less efficient priming of the transporter for ATP hydrolysis than in the case of the more stably engaged CoPP