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Animal experiments have shown that choline or carnitine supplementation markedly (approximately 30%) reduces reverse cholesterol transport (RCT) in mice compared to normal chow controls, a process that can be completely inhibited by oral broad-spectrum antibiotics (24)

Journal of Food Composition and Analysis, 100 , 103938

Cinar et al., 2007

The calcium overload activates calcium-dependent enzymes (e.g., calpain, nitric oxide synthase [NOS]), generating ROS and mitochondrial dysfunction, which triggers the release of apoptosis-inducing factor and cytochrome C, thereby activating caspase-9 and caspase-3