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The conversion of GPN to SFN transpires during the cutting or chewing of broccoli sprouts, a process that exposes GPN to the catalytic action of the myrosinase enzyme [18]

You may consider clinical assessment if: Pigmentation is long-standing or resistant to topical care Melasma remains persistent despite conservative management Post-inflammatory hyperpigmentation does not gradually fade Sun damage is extensive Treatment recommendations should always be individualised after medical evaluation

Although lipid peroxidation plays a major role in mediating ferroptosis, this biochemical response to oxidative damage also occurs in other types of RCD [201,202]