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Considering the physiological significance of copper as an important cofactor and its unique redox activity, copper homeostasis is essential for a variety of biological processes [1, 8]

This HBA1 variant is known as Hb Evans and is associated wild with mild hemolytic anemia and classified as UH

Changes in gut microbiota are considered one of the key factors triggering chronic inflammation, although the specific mechanisms remain unclear [9]

This is important for individuals in any high-activity lifestyle

Mechanistically, the combination treatment attenuates SIK3-potentiated mTOR-mediated aerobic glycolysis and suppresses AKT signaling, leading to G0/G1 phase cell cycle arrest and apoptosis in a SIK3-dependent manner