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Exome sequencing reveals VCP mutations as a cause of familial ALS

If methylation is impaired, less homocysteine enters transsulfuration which reduces cysteine production

ACSL4, acyl-CoA, synthetase long-chain family member 4

In vivo, LMPt was tested in an AsPC-1 mouse xenograft model, where it exhibited a 31.36% inhibitory effect, approximately eight times greater than of miriplatin alone [78]

Signals of thiomethyl metabolites were always low for blood samples collected less than 6h apart, showing that elimination of NAPQI (either after conjugation to glutathione or the antidote) is also subject to a delay in case of acute intoxication