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Temperature control is essential for stability

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doi: 10.1016/j.jconrel.2020.01.048 120 PoonJ-FZilkaOPrattDA

Firstly, activated NF-B and NLRP3 inflammasome in DN promotes inflammation and increases fibronectin and collagen deposition in kidney, 41,42 leading to thickening glomerular basement membrane, glomerular sclerosis, podocyte damage, and ultimately kidney fibrosis