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Pathological high intraocular pressure (pH-IOP) is the main cause of visual impairment in glaucoma patients, which can lead to RGC death and permanent visual impairment (Yao et al., 2023)

These phytochemicals principally interacted with pivotal neuro-inflammatory signaling waterfalls, improved brain enzymatic activity, decreased nitrosative stress and RNS formation, improved brain antioxidant defense, regulated of pro-inflammatory-related gene expression, restored the activity of astrocytes and microglial cells, modulated brain transcription factors expression, alleviated COXs expression, enhanced expression of anti-inflammatory genes, and protected brain neuronal cells (248, 401, 402)

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doi: 10.1016/j.cbi.2020.109178 130

Li J, Zhu S, Wang Y, Fan M, Dai J, Zhu C, et al