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Although we could not give a definitive answer to that because there was no statistically significant AE differences between group 1 and group 2, group 1 showed a numerical trend towards fewer TEAEs, fewer dropout rates due to AEs, and fewer moderate to severe AEs, suggesting that 15 mg/day dose-titration might be preferable than alternate dose titration (group 2)

Other Names for This Condition Hyperammonemia, type III N-acetylglutamate synthetase deficiency NAGS deficiency Additional Information & Resources Genetic Testing Information Genetic and Rare Diseases Information Center Patient Support and Advocacy Resources Clinical Trials Catalog of Genes and Diseases from OMIM Scientific Articles on PubMed References Caldovic L, Morizono H, Panglao MG, Cheng SF, Packman S, Tuchman M

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6.1.3 Complex I hypofunction stratification Multi-cohort and patient-derived data show that a biologically meaningful subset of idiopathic PD exhibits mitochondrial complex I deficiency aligned with higher ROS burden and clinical heterogeneity, supporting mitochondria-linked oxidative stress as a disease-relevantnot merely genericaxis (127)

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