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After 24 h of drug treatment or cystine starvation, 10 l of CCK-8 reagent was added to each well containing 100 l medium in total and the plate was incubated at 37 C, 5% CO 2 for 3 h

The plasma concentrations of the GLP-1 WT albiglutide-mimic and Tanzeum were comparable at the following time points, resulting in similar PK properties (Supplementary Fig