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It is therefore conceivable that multiple mechanisms are involved in CDDP resistance, including reduction of drug transport and increased DNA adduct tolerance and repair [9, 10]

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The following serious adverse reactions are discussed elsewhere in the labeling: Hepatic Injury [ see WARNINGS AND PRECAUTIONS (5.1)] Serious Skin Reactions [see WARNINGS AND PRECAUTIONS (5.2)] Allergy and Hypersensitivity [ see WARNINGS AND PRECAUTIONS (5.4)] 6.1 Clinical Trial Experience Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed cannot be directly compared to rates in other clinical trials and may not reflect the rates observed in practice

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[DOI] [PMC free article] [PubMed] [Google Scholar] Martin-Loeches I., Bermejo-Martin J.F., Valles J., Granada R., Vidaur L., Vergara-Serrano J.C., Martin M., Figueira J.C., Sirvent J.M., Blanquer J., Suarez D., Artigas A., Torres A., Diaz E., Rodriguez A., SEMICYUC/REIPI/CIBERES H1N1 Working Group Macrolide-based regimens in absence of bacterial co-infection in critically ill H1N1 patients with primary viral pneumonia