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Interestingly, NC and the lysozyme displayed opposing migration properties: while NC was detectable in the gel exposed to the conventional polarity, the lysozyme (both oxidized and non-oxidized) that has isoelectric point of 11.35 under given conditions migrated into the gel only upon inversion of the polarity (Supplementary Fig

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Further studies are needed to evaluate the mechanistic connection between mtDNA polymorphisms and mitochondrial-encoded peptides in T2DM