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In the Kmt2d +/Geo mouse model, treatment with KD for 2 weeks normalizes the global histone modification state corrects the neurogenesis deficiency in the granule cell layer of the dentate gyrus, and rescues the hippocampal memory defects (88)

Patients with a positive baseline serum pgRNA had a worse prognosis and a higher cumulative recurrence rate after systemic treatment(Figure 1)

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10.1016/j.cbd.2017.10.005 59 HberleinF.MingardoE.MertenN.Schulze KhlingN.-K.ReinoP.SimonK.et al (2022)