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Previous studies have shown that PGP9.5 cells were significantly decreased in the patients with slow transit constipation in inner circular layer (Geramizadeh et al., 2009)

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Inhibition of mTOR by rapamycin treatment or transient TSC2 expression 43 can also lead to a decrease in HIF-1 levels, and therefore could result in reduced HIF-1-dependent glycolytic and inflammatory gene expression 97

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