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The varying strategies of developing an ARKO line are important to note as characteristics such as the presence of the selection cassette, the promoter selected for transgene integration, the position of the loxP sites, or the utilized mouse background all likely contribute to differences in tissue selectivity, AR activity, and the resulting phenotypes [178, 201]

In this study, we revealed that high overexpression of SLC7A11 also promotes NADPH depletion and triggers disulfide stress and subsequent cell death under H 2 O 2 treatment, an oxidative stressinducing condition known to consume NADPH

These products are often found in the supplement aisle and positioned as solutions for gut health, inflammation, and joint support but their efficacy remains questionable