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Specifically for CYP/sEH metabolism, the partial least squares discriminant analysis performed on the samples found higher levels of 9,10-EpOME and 12,13-EpOME in the cerebrospinal fluid and a decrease in the ratio of 12,13-DiHOME/EpOME in the plasma in the AD group compared to the control group ( postmortem cerebral cortex samples, a positive correlation between various CYP-derived oxylipins and clinical phenotypes of AD were found, including 5-, 9-, and 12-HETE, 12-HEPE, 13-HpODE, 5,6- and 11,12-DHET, and 14,15-DiHETE (Kurano et al., 2022)

Interactions of dopamine, iron, and alpha-synuclein linked to dopaminergic neuron vulnerability in parkinsons disease and neurodegeneration with brain iron accumulation disorders

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