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While moderate SSG protects against irreversible cysteine oxidation (e.g., -SOH/-SO2H), severe oxidative stress drives pathological overoxidation, triggering cell senescence or death (98)

The most reasonable choice depends on the clinical objective, formulation quality, route, tolerance, convenience and evidence proportional to the claim being made

If the indication for its use is sound, however, an offending drug justifiably may be given despite modest shortening of red cell survival

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Therefore, attenuation of lipid peroxidation or oxidative stress by dietary antioxidant supplements during exercise is an effective strategy to enhance and/or maintain endurance performance